| Pair Name | Biochanin A, Temozolomide | ||
| Phytochemical Name | Biochanin A (PubChem CID: 5280373 ) | ||
| Anticancer drug Name | Temozolomide (PubChem CID: 5394 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Biochanin A, Temozolomide | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Induction-->Glycolytic to oxidative phosphorylation | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Down-regulation | Expression | EGFR | hsa1956 | |
| Down-regulation | Phosphorylation | MAPK3 | hsa5595 | |
| Down-regulation | Expression | MYC | hsa4609 | |
| Up-regulation | Phosphorylation | TP53 | hsa7157 | |
| In Vitro Model | U-87MG ATCC | Glioblastoma | Homo sapiens (Human) | CVCL_0022 |
| T98G | Glioblastoma | Homo sapiens (Human) | CVCL_0556 | |
| Result | Chanin A significantly enhanced the anticancer efficacy of temozolomide in GBM cells. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combination of Biochanin A and Temozolomide Impairs Tumor Growth by Modulating Cell Metabolism in Glioblastoma Multiforme. Anticancer Res. 2019 Jan;39(1):57-66. doi: 10.21873/anticanres.13079. | Click |
